Cancer Hotspots

Gene

Hotspot

Cancer

Application

ABL1

exon4

exon6

T315I

Leukemia

Tyrosine kinase inhibitor (TKI) therapy

AKT1

E17K

G49A

Multiple cancers

AKT inhibitor sensitivity

ALK

exon25

Neuroblastoma/ NSCLC

Tyrosine kinase inhibitor (TKI) therapy

APC

codon1286-codon1513

Colorectal cancer

Cancer prognosis

BRAF

exon15

V600E

Multiple cancers

Cancer prognosis

CDH1

exon7-exon10

Gastric cancer

Cancer prognosis

CSF1R

exon7

exon22

Renal cancer

Tyrosine kinase inhibitor (TKI) therapy

CTNNB1

exon3

Multiple cancers

Cancer prognosis

EGFR

exon18-exon21

NSCLC

TKI therapy resistance and sensitivity

ERBB2

exons 8, 17, 19, 20, 21

Multiple cancers

Cancer prognosis

EZH2

exon15

Multiple cancers

EZH2 inhibitors

FBXW7

exon9 exon11/ R465, R479, R505

Multiple cancers

mTOR inhibitors

FGFR1

codons Asn546 Lys656

Multiple cancers

FGFR inhibitors

FGFR2

exons IIIa, IIIc, codon290

Multiple cancers

FGFR inhibitors

FGFR3

R248C

Multiple cancers

FGFR inhibitors

GNA11

R183, Q209

Melanoma

Cancer prognosis

GNAQ

R183, Q209

Melanoma

Cancer prognosis

GNAS

exon8 exon9/R201, Q227

Multiple cancers

Cancer prognosis

HNF1A

exon4

Pancreatic cancer

Cancer prognosis

HRAS

exon2 exon3/codon12 codon61

Multiple cancers

RAS inhibitors

IDH1

R132/exon4

Multiple cancers

IDH1 inhibitors

IDH2

exon4/R140, R172

Multiple cancers

IDH2 inhibitors

JAK2

exon12 exon14

Myeloproliferative neoplasms

Hydroxyurea

JAK3

exon13

Multiple cancers

Kinase inhibitors

KIT

exon2 exon8-11/L576, K642, W557-V560, and D816-A829

Multiple cancers

KIT inhibitors

KRAS

exon2 exon3/codon G12

Colorectal cancer

RAS inhibitors

MLH1

exon15 exon16 exon18

Colorectal cancer

5-FU

MPL

exon10

Myeloproliferative neoplasms (MPNs)

Cancer treatment

NOTCH1

exon26 exon27 exon34

Multiple cancers

NOTCH inhibitors

NPM1

exon12

AML

Cancer prognosis

NRAS

exon2 exon3/codon Q61

Melanoma

MEK inhibitors

Immune therapy

PDGFRA

exon12 exon14 exon18

Gastrointestinal stromal tumors

Inhibitors of PDGF receptor kinases

PIK3CA

H1047R, E542K and E545K

Breast cancer

PIK3CA inhibitors

PTEN

exon5 exon7

Multiple cancers

Targeted chemotherapy

PTPN11

exon3 exon13/ codon76

Multiple cancers

anti-SHP2 drugs

RET

codon790 codon791

Multiple cancers

RET kinase inhibitors

SMAD4

1244-1247delAGAC

Colorectal cancer

5-FU

Cancer prognosis

SMARCB1

exon9

Sinonasal carcinomas

rhabdoid tumors

Cancer classification

TP53

exon2-exon11/codons 175, 248, and 273

Multiple cancers

MDM2/4 antagonists

PRIMA-1

PRIMA-1MET

Nutlin

 

VHL

codons95-123

Von Hippel-Lindau disease

Antiangiogenics

 

آزمایشگاه ژنتیک پزشکی تهران

ساعات کاری: شنبه تا چهارشنبه 7:30 صبح تا19:30 شب پنج شنبه 7:30 صبح تا 15:30 ظهر

عکس ها